Theories of Action of LOCAL ANESTHESIA

THEORIES OF LOCAL ANESTHETIC ACTION -local anesthetics bind to sodium channels in the inactive state therefore preventing the next subsequent channel activation -inhibition of subsequent channel activation prevents membrane depolarization and therefore inhibits action potential propagation critical volume hypothesis: may penetrate the membrane creating and expansion to the membrane altering the ion channels surface charge theory: inhibition of depoarization due to partial penetration of local anesthetics within the axon